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"We found that stem cells, developed by us, when injected in the damaged portion of the brain did trigger development of new brain cells without any life-threatening side-effects," S Prabhakar, head of the department of neurology, PGI Chandigarh said.
"This is the first time that interactions between the two kinds of cells (injected cells and host cells) worked out," he said.
Five centres across the country, including AIIMS, are conducting studies on the stem cell treatment of stroke, according to Prabhakar.
Brain stroke occurs when a blood vessel carrying oxygen and nutrients to the brain is blocked by a clot or bursts, causing the brain to starve.
"If deprived of oxygen for even a short period of time, the brain cells begin to die. Once this happens the part of the body controlled by that section of the brain is affected, causing paralysis," M V Padma, a neurologist at AIIMS, said.
Human trials for the study will begin this month. "From January onwards the trials in human being will start. In our experiment we wanted that once the stem cells were injected, it should reach and form new cells in the damaged destination and it really did." Prabhakar said.
There are two types of strokes. In the first, blood clots in vessels leading to blocking of the arteries in the brain. The second type occurs when a blood vessel ruptures causing a bleeding also known as hemorrhagic stroke.
There are also "mini-strokes" which is often ignored and which if left untreated will lead to full blown strokes.
Brain stroke is the third largest killer in India after heart attack and cancer and the second largest in the world, according to the World Health Organisation.
A WHO study, stated that the incidence of the disease in India to be around 130 per 100,000 people every year and says about 20 per cent of heart patients are susceptible to it.
"For this study, we injected human stem cells into adult mice only after deliberately inducing brain stroke in them," Prabhakar said while explaining the experiment on the mice.
For this, the blood supply in the brain of mice was cut off for just 15 minutes and then restored. "That causes massive damage to the brain. It's the sort of thing that happens when you have a cardiac arrest. Then human cells were injected and within about a week, the responses of mice improved dramatically," he said.
Compared to a heart attack, the awareness about brain strokes, is limited," Prabhakar added.
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I am sayed from tirupati, my father attacked with brain stroke on 26th sep 2011 and he got on right side weakness.He can able to move his hand and leg upto 75 percent.Voice clarity was increases after speech therapy but not the optimum range.urination was under control during day time(time voiding) and not in night time.Now we are u/medication of CMC vellore.Is the damaged brain tissue spreads over the brain or restricted to particular portion only.Is that Blood clot automatically dissolves after some time.what is the life span of patients after the stroke. Please clarify my doubts.
hello sir this is basha from guntur i dont no english well so iam typing in telugu language ma nanna garu 9 months nunche peralasis tho badha padutunaru sir memu manipal hospital lo treatment cheyenchamu treatment baga karchu iendi sir but no use sir present ma nanna nadavalekapotunaru ma nanna age 51years sir ma nanna ne chustunta chala badha ga undi sir meru em anna treatment unda sir naku 2sis unnaru sir vallke marrage kaledu naku 15,000 per month vastundi sir naku every month chala burden g undi sir present maa daddy ke phyotherpy chestunamu sir kane result raledu sir ma house lo daily narakum ga undi sir ma dad ne chuse mummy badha padutundi anta kuda chala edi ga undi sir daya chese me kallu patukuntanu sir ma dad ke tondaraga nade che treatment unte chepandi sir ma dad left sir peralssis vachindi sir left hand panecheyadum ledu left leg konchum light ga nedustunaru sir leg fold kavatum ledu sir daychese sir please please please pleaseplease pleaseplease please sir naku em
kindly advise for brain cell treatment for regeneration of brain cell.
My father got brain stroke on 14-2-2011,he got paralysis of left side, has infarct on temporal lobe of size 59x42mm as shown in CT scan,he is getting treatment at Tanda medical college,He has got medicinal treatment only, drugs they are using now are aspirin,Piaracetam and multivitamin and with this he is getting physiotherapy and panchkarma at ayurvedic college Paprola,he is eating well,conciosness almost normal,urination normal,voice clearity increases but not optimum but has constipation and still paralytic with no movement at all..please suggest me if better treatment than this is possible..should I go to AIIMS or some other institute and what will be the cost...
my mother suffering from paralysis since june2008 and now she is badridden like comma stage after brain stroke. is it possible to recover her from this stage by using stems cells. according to MRI there are INFRACTS in the Brain
I'm srinivas rao from vizag(A.P)i'm 30 years old,suffered from paralytic stroke in 2008.affected left upper,lower limbs.am able to walk slowly after lot of physiotheraphy sessions bt cannot run like how i used to as a sportsman earlier.cannot type with left hand at work.almost everything slips away from left hand.please suggest/advise to put my life back on normal track.I have tried Noni-ayur(tonic)and Wrudved(tab)but all in vain.fingures on left hand have no co-ordination.one can easily find me limping slightly while i take a walk.Itry to do stretching excercises but fail to do it.please help me.I'm in Vishakapatnam(A.P).Please suggest the nearest center i can visit for treatment. Thankyou.
I got a stroke on 31st august last year. The right portion of my body got paralysed. I also lost my ability to speak. I have recovered quite a lot now but still i get stuck up while speaking and my voice is not clear. Moreover, my right hand has not recovered completely. The wrist portion is still left. Can you please send me the details of the places in india which have stem cell therapies and can help me ?
MY FATHER - 82 YEARS GOT A STROKE AND IS BEDRIDDEN HE CANNOT MOVE OR RECOGNIZE AND HAS PARALYSIS OF LEFT ARM AND TONGUE AND CANT SPEAK CAN WE GIVE STEM CELL THERAPY
My Father has been suffering from right side paralysis and has also lost his speech as a result of a stroke in Dec 06'. Please send me any relevant details regarding this treatment as I would love to give him every chance to get back on his feet.
I AM SUFFERING FROM PARALYSIS FOR THE LAST 5 YRS. I AM NOT ABLE TO WALK AND SPEAK PROPERLY. THIS HAS CAUSED BY HIGH BP. PONTINE BLEED IN THE BRAIN. MY LEFT SIDE IS HEAVY AND NOT BALANCING. I HEARD THE STEM CELL THERAPY WILL CURE THE DISEASE. IS THERE ANY HOSPITAL AND EXPERT DOCTOR IN MUMBAI WHO CAN PERFORM STEM CELL SUCCESSFULLY AND WHAT IS THE COST OF IT? I AM STAYING IN PUNE. SO THE NEAREST PLACE IS MUMBAI.
My mother has stroke on 19th jan 2009, she is presently at home and having paralysis. Kindly give me the complete details of this treatment. The contact information as well as the cost in this therapy. Thanks in advance
Stroke type:Blood cloting in vessels leading to blocking of the arteries in the brain. My father has stroke on 23rd dec.'07 and he is suffering from right paralysis. Kindly give me the complete details of this treatment. The contact information as well as the cost in this therapy
Stroke type:Blood cloting in vessels leading to blocking of the arteries in the brain. My father has stroke on 23rd dec.'07 and he is suffering from right paralysis. Kindly give me the complete details of this treatment. The contact information as well as the cost in this therapy.
My father is suffering from left paralysis from last 3 years. Kindly give me the complete details of this treatment. The contact information as well as the cost in this therapy.
My mother has stroke on 15th Aug. 2008, she is presently hospitalized and having paralysis. Kindly give me the complete details of this treatment. The contact information as well as the cost in this therapy.
My father has stroke on 10th September 2009, he is presently hospitalized and having paralysis. Kindly give me the complete details of this treatment. The contact information as well as the cost in this therapy. Thanks in advance
My Sister is paralysed for almost 8 years now and recently she lost her husband who was taking care of her. Please send me any other relevant details of this treatment and I am sure she will be ready for any trials on stemcell therapy. Thanks.
i have brain stroke so this treatment use for me.
my sister" daughter is suffring from spainal cort injurey during an accident with a car . her spainal cort is damezd and some vains are cut in spainal cort . her lowr porshion is not working . plz help me and tell me what can i do for that her age is 1.5 years
my sister in law got paralysis attack on 31/12/2008.her left side got paralysied.iwant to know will srem cell treatment help her
My mom's left side has been paralysed 4 the last 3 months..can u give me the contact details of the doctors working on this...also does it have any side-effects...in which country other than india...these surgeries are successfully done...?
i am a patient of brain stroke for last 40 yrs that rendered my right side weak.hence i am unable to perform stressful works. year after year this weakness is increasing. after hearing about stemcell therapy i am quite hopeful.can you send me the mob no or email adresses of the doctors working on this.i am ready for experimental trials on me for stemcell therapy at pgi chandigarh or aiims delhi.thanks
This is a great achievement by an Indian Doctor.I hope he conducts the test on humans also successfully.There are plenty of kids suffering from brain diseases in our country.They have some hope now.please give contact details of the doctor so that more details on the same can be obtained.
i have brain stroke so is this treatment use for me?
Hello, Very encouraging development.Can I get the contact details of the doctors and hospitals who are working on this ?My father suffered Paralysis couple of years ago