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AIIMS drops two stem-cell trials due to poor patient response

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Vidya Krishnan,Vidya Krishnan

Posted: Feb 07, 2009 at 0004 hrs IST

New Delhi Stem-cell research in the city received a setback recently when the All India Institute of Medical Sciences (AIIMS) was forced to abort two ongoing trials because the patient pool did not respond to the treatment.

The trials were being carried out on those suffering from muscular dystrophy and Motor Neuron Disease (MND).

Doctors in charge of the trials have said they are disappointed with the results. Professor Madhuri Behari, head of AIIMS’ neurology department, said: “A lot still needs to be done on this subject. It is unfortunate these trials had to be abandoned. The patients underwent stem-cell therapy for over a year. They showed little progress initially but none after that.” Both trials were conducted by her department.

The advanced research has also failed to work on patients with cardio-vascular diseases or those who suffered strokes. Initial results had indicated the doctors were on the right track, but that was it.

The treatment of heart and stroke patients began in 2005 under the aegis of former AIIMS director Dr P Venugopal. The immediate results had excited experts, who thought the efficacy of stem-cell therapy might have been proved beyond doubt. But three years on, they have realised there is need for more extensive research before one can emphatically talk about the effects of this treatment.

Dr Sujata Mohanty, in-charge of the stem-cell facility at AIIMS, said: “Trials done on heart and stroke patients have not been completely evaluated. It won’t be correct to say that we have achieved the desired results.”

Dr P Venugopal, under whose guidance the stem-cell facility in the institute took shape, is not worried by the results. He said: “It is an established fact that stem cells are effective. We need to read the reasons behind the recent failures. This can happen if the follow-up is not according to laid down rules.”

Apart from the two trials, doctors are at present working on stem-cell research in strokes, cerebral palsy, injuries of the spinal cord and Parkinson’s Disease. Most trials are assisted by the Department of Science and Technology.

Though disheartened, doctors are hopeful. Dr Mohanty said: “We might not have got all the answers now. We don’t know which group benefitted more from the trials — those with chronic diseases or the ones diagnosed recently. The trial is still in its infancy.”

Stem-cell therapy is a cutting-edge technique that can treat diseases for which there is still no cure.

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stem cell treatment for C P by Meenakshi Banerji on 03 Sep 2011

My ten years old daughter"Durga"suffers from cerebral palsy,she's also slightly autistic,i'm looking forward to some authentic support from institutions like AIIMS'those can promise substantial improvement in her through STEM CELL THERAPY.thanx!

TREATMENY FOR MUSCULAR DYSTROPHY by BSINGH on 22 Mar 2011

MY NEARBY RELATIVE 7YR OLD CHILD MALE IS SUFFERING FROM MD WE LOOK FOR CURE/TREAT MD LIKE PHYSIO/ AYURV/STEM ETC PLEASE GUIDE US.

want to know about stem cell treatment for cerebral atrophy by CHANDER BHAN on 10 Nov 2010

my brother had sever headinjury&after that cardiac arrest at Forties hospital at Mohali last year.At present he is invegetative stage&having cerebral atrophy.I hope stem cell treatment help him. Can we go for this treatment at AIIMS.thanks

cure for muscular dystrophy by rakesh thapa on 18 Oct 2009

My son, aged 8 yrs is suufering from DMD. He shows Gower signs. Presently he is under physiotherapy,ayurvedic treatment including massage. His CPK levels has gone down from 5400 to 900 in approx 18 months of medication. Calf muscles are soft as of now. Only problems is climbimg stairs, walking fast and running. Falling has reduced considerably. DMD PCR test has been negative but symptoms of DMD exist. Muscle byopasy has not been done as yet. Please guide me as what to do? Whwere can i get special soes for him made so that he does not walk on toes and gets some support?

ABC by abc on 18 Apr 2009

I dont understand why people dont let advancement in medical field?Stem cell is for people facing serious illness.PLs let the research go on.Its a blessing for paraplagic people.thanks!!!!!!!

stemcell reasearch by Dr V Rajeshwari on 08 Apr 2009

saddened at the state of affairs.Any reasearch is time and energy consuming and yeilds results after repeated trials. The good work started by the visionary should be continued not only in the interest of the patients but also to maintain the icon status of the institute.

stem cell for motor neuron desease by Manoj on 15 Feb 2009

My brother is suffering from Motor Neuron desease is there any hope for him to get treatment from stem cell technology

stem cell by piyush sharma on 12 Dec 2009

hi manoaj i m apatient of paraplagia and having the treatment of stem cells by which i m getting some improvement in myself this therapy is good for this mnd

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